|
|
H+ + 5-fluorocytosine + H2O <=> 5-fluorouracil + NH3
|
3.5.4.1
cytosine deaminase
3.5.4.21
creatinine deaminase
|
–
–
|
|
|
BRENDA:
BS140967
MetaCyc:
RXN-14129
|
|
|
|
5-fluorouracil + NADPH <=> 5-fluoro-5,6-dihydrouracil + NADP+
|
1.3.1.1
dihydropyrimidine dehydrogenase (NAD+)
1.3.1.2
dihydropyrimidine dehydrogenase (NADP+)
|
–
–
|
K
|
|
BRENDA:
BS231910
KEGG:
R08226
|
|
|
|
5-fluorouracil + 5-phospho-alpha-D-ribose_1-diphosphate <=> 5-fluoro-UMP + diphosphate
|
2.4.2.10
orotate phosphoribosyltransferase
2.4.2.9
uracil phosphoribosyltransferase
|
–
–
|
K
|
|
BRENDA:
BS355257
KEGG:
R08231
|
|
|
|
5-fluorouridine + phosphate <=> 5-fluorouracil + alpha-D-ribose_1-phosphate
|
2.4.2.2
pyrimidine-nucleoside phosphorylase
2.4.2.3
uridine phosphorylase
2.4.2.4
thymidine phosphorylase
|
–
–
–
|
K
|
|
BRENDA:
BS355333
KEGG:
R08229
|
|
|
|
5-fluoro-2''-deoxyuridine + phosphate <=> 5-fluorouracil + 2-deoxy-D-ribose_1-phosphate
|
2.4.2.2
pyrimidine-nucleoside phosphorylase
2.4.2.3
uridine phosphorylase
2.4.2.4
thymidine phosphorylase
|
–
–
–
|
K
|
|
BRENDA:
BS355334;
BS375961
KEGG:
R08230
SABIO-RK:
10166
|
|
|
|
5''-deoxy-5-fluorouridine + phosphate <=> 5-fluorouracil + 5-deoxy-D-ribose_1-phosphate
|
2.4.2.3
uridine phosphorylase
2.4.2.4
thymidine phosphorylase
|
–
–
|
K
|
|
BRENDA:
BS355335
KEGG:
R08222
SABIO-RK:
10162
|
|
|
|
Tegafur + reduced_flavodoxin + O2 <=> 5-fluorouracil + 1,4-butanedione + flavin + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
K
|
|
KEGG:
R08225
|
|
|
|
carmofur <=> 5-fluorouracil
|
not assigned
|
–
|
K
|
|
KEGG:
R11890
|
|
|
|
5-fluoropyrimidine + H2O + O2 <=> 5-fluorouracil + H2O2
|
1.2.3.1
aldehyde oxidase
|
–
|
|
|
BRENDA:
BS258181
|
|
|
|
5-Fluoroorotate <=> 5-fluorouracil + CO2
|
4.1.1.23
orotidine-5'-phosphate decarboxylase
|
–
|
|
|
BRENDA:
BS444817
|
|
|
|
5-fluorouridine + H2O <=> 5-fluorouracil + D-ribose
|
3.2.2.3
uridine nucleosidase
3.2.2.8
ribosylpyrimidine nucleosidase
|
–
–
|
|
|
BRENDA:
BS372132
|
|
|
|
2''-deoxyadenosine + 5-fluorouracil <=> 2''-deoxy-5-fluorouridine + adenine
|
2.4.2.6
nucleoside deoxyribosyltransferase
|
–
|
|
|
BRENDA:
BS387064
|
|
|
|
2'-deoxyadenosine + 5-fluorouracil <=> adenine + deoxy-5-fluorouridine
|
2.4.2.6
nucleoside deoxyribosyltransferase
|
–
|
|
|
BRENDA:
BS354859
|
|
|
|
2''-deoxyadenosine + 5-fluorouracil <=> 2''-deoxy-D-ribosyl-5-fluorouracil + adenine
|
2.4.2.6
nucleoside deoxyribosyltransferase
|
–
|
|
|
BRENDA:
BS422333
|
|
|
|
thymidine + 5-fluorouracil <=> thymine + 2''-deoxy-5-fluorouridine
|
2.4.2.6
nucleoside deoxyribosyltransferase
|
–
|
|
|
BRENDA:
BS354902
|
|
|
|
5-fluorouracil + NAD+ <=> 5-fluoro-5,6-dihydrouracil + NADH
|
1.3.1.1
dihydropyrimidine dehydrogenase (NAD+)
|
–
|
|
|
BRENDA:
BS396006
|
|
|
|
5-fluorouracil + NAD+ <=> alpha-fluoro-beta-alanine + NADH + H+
|
1.3.1.1
dihydropyrimidine dehydrogenase (NAD+)
|
–
|
|
|
BRENDA:
BS396008
|
|
|
|
dihydrofluorouracil + NADP+ <=> 5-fluorouracil + NADPH + H+
|
1.3.1.2
dihydropyrimidine dehydrogenase (NADP+)
|
–
|
|
|
BRENDA:
BS413351
|
|
|
|
fluorouridine + phosphate <=> 5-fluorouracil + alpha-D-ribose_1-phosphate
|
2.4.2.3
uridine phosphorylase
|
–
|
|
|
BRENDA:
BS376805
|
|
|
|
5-fluoro-2'-deoxyuridine + phosphate <=> 5-fluorouracil + 2-deoxy-D-ribose
|
2.4.2.4
thymidine phosphorylase
|
–
|
|
|
BRENDA:
BS355330
|
|
|
|
5''-deoxy-5-fluorouridine + phosphate <=> 5-fluorouracil + 2-deoxy-alpha-D-ribose_1-phosphate
|
2.4.2.2
pyrimidine-nucleoside phosphorylase
|
–
|
|
|
BRENDA:
BS399740
|
|
|
|
5-fluorouracil-mismatched_double-stranded_DNA + H2O <=> 5-fluorouracil + double-stranded_DNA_with_abasic_site
|
3.2.2.27
uracil-DNA glycosylase
3.2.2.29
thymine-DNA glycosylase
|
–
–
|
|
|
BRENDA:
BS398684
|
|
|
|
2''-deoxyuridine + 5-fluorouracil <=> 5-fluoro-2''-deoxyuridine + Uracil
|
2.4.2.2
pyrimidine-nucleoside phosphorylase
|
–
|
|
|
BRENDA:
BS434999
|
|
|
|
5-Fluoroorotate <=> 5-fluorouracil
|
4.1.1.23
orotidine-5'-phosphate decarboxylase
|
–
|
|
|
BRENDA:
BS444816
|
|
|
|
5-fluorouracil + H2O <=> 2-fluoro-3-ureidopropionic_acid
|
3.5.2.2
dihydropyrimidinase
|
–
|
|
|
BRENDA:
BS383956
|
|
|
|
ATP + H2O + 5-fluorouracil <=> ADP + phosphate + 5-fluorouracil
|
7.6.2.2
ABC-type xenobiotic transporter
|
–
|
|
|
BRENDA:
BS444938
|
|
|
|
5-fluorouridine + phosphate <=> 5-fluorouracil + alpha-D-ribose_1-phosphate
|
2.4.2.3
uridine phosphorylase
2.4.2.4
thymidine phosphorylase
|
–
–
|
|
|
SABIO-RK:
10164
|
|